WebThe determination of molecular features that mediate clinically aggressive phenotypes in prostate cancer remains a major biological and clinical challenge 1,2.Recent advances … WebApr 11, 2024 · This paper proposes the Biological Factor Regulatory Neural Network (BFReg-NN), a generic framework to model relations among biological factors in cell systems and is capable of merging most existing biological knowledge into the model, including the regulatory relations among genes or proteins. Genes are fundamental for …
Biologically informed deep neural network for prostate …
WebSep 17, 2024 · GenNet is a freely available, end-to-end deep learning framework that allows researchers to develop and use interpretable neural networks to obtain novel insights … WebHere we developed P-NET-a biologically informed deep learning model-to stratify patients with prostate cancer by treatment-resistance state and evaluate molecular drivers of treatment resistance for therapeutic targeting through complete model interpretability. We demonstrate that P-NET can predict cancer state using molecular data with a ... green mountain boxwood buxus green mountain
Physics-informed machine learning Nature Reviews Physics
WebFigure 1.Physics-informed neural networks for activation mapping. We use two neural networks to approximate the activation time T and the conduction velocity V.We train the networks with a loss function that accounts for the similarity between the output of the network and the data, the physics of the problem using the Eikonal equation, and the … Web1 day ago · In this paper, we propose the Biological Factor Regulatory Neural Network (BFReg-NN), a generic framework to model relations among biological factors in cell systems. BFReg-NN starts from gene expression data and is capable of merging most existing biological knowledge into the model, including the regulatory relations among … WebDec 1, 2024 · Biologically-informed neural networks (BINNs), an extension of physics-informed neural networks [1], are introduced and used to discover the underlying dynamics of biological systems from sparse experimental data. In the present work, BINNs are trained in a supervised learning framework to approximate in vitro cell biology assay … green mountain boxwood buxus