Cisplatin excretion

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August undefined, 2024

Web1152 rows · Jun 13, 2005 · Cisplatin may decrease the excretion rate of … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

DRUG NAME: Cisplatin - BC Cancer

Webof cisplatin with urine from healthy subjects, except that the proportions are different. The parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the dose excreted within one hour after administration of 50 mg/m2. The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and WebApr 12, 2024 · Cisplatin is a platinum-based chemotherapy agent that currently used as front-line therapy in the treatment of various solid organ cancers, including head and neck, lung, testis, ovary, breast, bladder cancer and sarcoma [1–7]. The therapeutic effects of cisplatin are significantly improved by dose escalation. rawcliffe idb

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http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebCisplatin (PIM 132) Cisplatin 1. NAME 1.1 Substance 1.2 Group 1.3 Synonyms 1.4 Identification Numbers 1.4.1 CAS 1.4.2 Other Numbers 1.5 Brand Names, Trade Names 1.6 Manufacturers, Importers 1.7 Presentation, Formulation 2. SUMMARY 2.1 Main Risks and Target Organs 2.2 Summary of Clinical Effects 2.3 Diagnosis WebPharmacologic i. Administer fluids to dilute serum Ca and promote excretion by kidneys ii. 0.9% NS IV iii. Diuretic: furosemide (Lasix) iv. Calcitonin (IM injection) useful for patients with heart disease or kidney injury. Taylor Stinson 11 v. Corticosteroids may reduce bone tumors vi. Mithramycin inhibits bone resorption & lowers serum Ca level d. simpleclub planetarische zirkulation

Effect of time of cisplatin administration on its toxicity and

WebÀ la suite d'un diagnostic de cancer de l'ovaire, la prise en charge thérapeutique constitue une étape déterminante dans la survie des patientes atteintes. Actuellement, la plupart de celles-ci subiront une cytochirurgie suivie d'une chimiothérapie standard comprenant du Cisplatin (ou Carboplatin) et du Paclitaxel. Malgré une réponse initiale adéquate, il a été … Webof cisplatin, the fecal excretion of platinum appears to be insignificant. INDICATIONS . Cisplatin Injection is indicated as therapy to be employed as follows: Metastatic … rawcliffe jfcWebIn comparison with cisplatin, carboplatin has longer half-lives of ultrafilterable platinum (23 and 120 min versus 6 and 36 min for distribution and initial elimination half-lives, respectively) and a higher cumulative urinary platinum excretion (77 versus 28% of the dose in 24 h), both due to the lower protein binding of carboplatin. rawcliffe house farm

"WebSep 18, 2024 · Theoretically, cisplatin may not be as useful for slow-growing tumors. The drug is primarily excreted in the urine, with 10% in the bile. Its initial half-life is approximately 20 to 30 minutes, with a terminal … " - Cisplatin excretion

Cisplatin excretion

Cisplatin decreases renal cyclooxygenase-2 expression and

WebOct 13, 2024 · Cisplatin is mainly cleared by the kidney through glomerular filtration and tubular excretion, resulting in a higher concentration of this drug in the kidney than in other organs. Renal... WebDec 26, 2024 · Increased excretion of phosphate occurs primarily in the renal system. The proximal renal tubule reabsorbs up to 70% of filtered phosphate normally, and the distal tubule reabsorbs up to 15% of filtered phosphate. ... cisplatin, or pamidronate, current treatment for diabetic ketoacidosis, and any hospitalization requiring an Intensive care …

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WebAug 1, 2024 · Cisplatin (CDDP) is an important anticancer drug. A common side effect of CDDP is renal salt and water-wasting syndrome (RSWS). The origin of RSWS is obscure. ... The effects of CDDP and benzamil (BZM), a blocker of ENaC, on excretion of a sodium load were quantified. Similar to BZM, CDDP facilitated renal Na + excretion. To directly … WebAbstract. The purpose of this study was to determine long-term renal platinum excretion after chemotherapy with cisplatin. We examined urinary platinum concentrations in 23 …

WebApr 24, 2024 · The mean cisplatin excretion was 70.3 ± 64.4, 7.3 ± 6.3, and 5 ± 4 μg/mg creatinine at 0-12, 12-24, and 24-48 h, respectively. Statistical analysis showed that the …

WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and hematological toxicity potentiated by other chemotherapeutic agents. Due to the predominant renal excretion of cisplatin, the concentration in tubular epithelial cells is 5 times higher than in blood. WebJan 12, 2024 · Since cisplatin resistance was generally associated with increased cisplatin export , we first analyzed the expression profile of genes annotated to regulation of cell excretion in a dataset GSE15120 from the GEO. The dataset comprises six pairs of parental and cisplatin-resistant HeLa cells.

WebDecreased cisplatin excretion: Nakamura et al. (2010) Cisplatin metabolism: Acivicin: GGT inhibition: Increased cell viability: Townsend and Hanigan (2002) Cisplatin metabolism: Aminooxyacetic acid: Cysteine conjugate β-lyase inhibition: Increased cell viability: Townsend and Hanigan (2002) Fig. 1.

WebSep 15, 2024 · It is therefore not limited to elucidating the effects of drugs on organisms and cell cultures etc., but also includes its application for tracing a drug and its metabolites, from entry into the body to excretion. We also wish to examine applications that investigate the re-emerging role of the gut microbiota in these processes. simple club polymerisationWebSep 6, 2024 · The parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the dose excreted within one hour after administration of 50 mg/m2. The … simple club pythagorasWebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … simple club reduktion und oxidationWebCisplatin, a platinum-based chemotherapy agent, is commonly used in treating cancers that may affect women of childbearing age, including cervical cancer, triple-negative breast cancer, and pediatric tumors in adolescents. simpleclub regenwaldhttp://www.bccancer.bc.ca/drug-database-site/drug%20index/cisplatin_monograph.pdf simple club relativitätstheorieWebThese effects are due to renal tubular damage. Cisplatin greatly increases the urinary excretion of magnesium and calcium; increased excretion of potassium, zinc, copper … simpleclub redoxreaktionenWebSep 15, 2024 · Cisplatin may cause serious side effects including: pain, burning, redness at the injection site, numbness, tingling, coldness or blude discoloration of the hands of … simple club powerpoint