Dichloromethane mutagenicity

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August undefined, 2024

WebDichloromethane was originally selected for substance evaluation in order to clarify concerns about: - Carcinogenic - Suspected mutagenic - Suspected reprotoxic - … WebThe results suggest that if an interaction between DCM and GSH is required for the activation of DCM to a bacterial mutagen, it occurs at low levels of endogenous GSH and is not significantly affected by GSH supplementation. Dichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a …

Mutagenicity Evaluation of Methylene Chloride-final …

WebNov 28, 2016 · 1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees … WebThe dichloromethane extracts of SRM 1649 and SRM 1650 contained direct-acting mutagens in Salmonella strains TA98 and TA100; SRM 1650 was significantly more potent than SRM 1649 in either strain. Addition of S9 caused a large decrease in mutagenicity of each extract, although SRM 1650 remained more potent. how is the rock so big

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http://www.feql.wsu.edu/MSDS/Dichloromethane.pdf WebProduct name : Dichloromethane Product Number : 270997 Brand : Sigma-Aldrich Supplier : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +1 800-325-5832 ... Germ cell mutagenicity Genotoxicity in vivo - rat - Oral DNA damage Carcinogenicity Carcinogenicity - rat - Inhalation Tumorigenic:Carcinogenic by RTECS … WebIn vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats. In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes … how is the rose used

Mutagenicity and chemical analysis of sequential organic ... - PubMed

Enzyme-mediated dichloromethane toxicity and mutagenicity of …

WebThe mutagenicity of dichloromethane was evaluated in Salmonella bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538 and Saccharomyces cerevisiae yeast … WebJul 1, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions. However, whether the GSTT1-mediated step of t … how is the roman army organisedWebMutagenicity Genotoxicity in vivo - rat - Oral DNA damage Embryotoxicity Not Available Specific Target Organ Toxicity-single exposure ... Flammable liquids, toxic, n.o.s. (methanol and dichloromethane), 3, (6.1), pg II . Revised on 09/26/2024 Page 7 of 7 15. REGULATORY INFORMATION TSCA Inventory Status All ingredients are listed on the … how is the rock doing

"WebTheir mutagenicity was examined with Salmonella typhimurium TA98 in presence or absence of S9 mix. The total mutagenic activity of the acetone extract was 1.8-7.0-fold that of the dichloromethane extract. ... However, the amount of pyrene in the dichloromethane extract was much higher than in the acetone extract. These results indicate that the ... " - Dichloromethane mutagenicity

Dichloromethane mutagenicity

CDC - NIOSH Pocket Guide to Chemical Hazards - Methylene …

WebDichloromethane, Methylene dichloride CAS No. 75-09-2 RTECS No. PA8050000. DOT ID & Guide. 1593 160. Formula. CH₂Cl₂ ... Webfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, namely 1) mutagenicity at the gene level, 2) chromosome breakage and/or rearrangements (clastogenicity), and 3) numerical chromosome aberrations (aneuploidy). This

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WebBiodegradation of dichloromethane (DCM) to environmentally acceptable products was demonstrated under methanogenic conditions (35 degrees C). When DCM was supplied … WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases Daniel Gisi, Thomas Leisinger & …

WebDichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a bacterial mutagen. It has been suggested that the bacterial mutagenicity of DCM is mediated by glutathione (GSH) conjugation. The involvement of endogenous and exogenous GSH in the con … WebJan 1, 1978 · The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was …

WebAgency for Toxic Substances and Disease Registry WebSep 1, 1983 · The metabolic activation and mutagenicity of dichloromethane and chlorofluoromethane were investigated using rat liver fractions and Salmonella typhimurium strain TA100. Both dihalomethanes gave a mutagenic response without the addition of rat-liver fractions. This response has been shown to be due to bacterial metabolism of the …

WebSix chicken-essence concentrates (CEC) or their dichloromethane extracts (DECE) showed inhibition of the mutagenicity of indirect environmental mutagens such as 2-amino-3-methylimidazo[4,5- f]quinoline (IQ), 3-amino-l-methyl-5-H-pyrido[4,3-b] indole (Trp-P-2), and benzo[a]pyrene (B[a)P), but contrarily had no effect on direct environmental ...

how is the root hair cell adaptedWebMethylene Chloride is a clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of … how is the rorschach test usedWebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases. The kinetic properties of bacterial … how is the root hair cell adapted to its jobWebDichloromethane caused a reproducible positive response in bacterial tester strains TA98, TA100, TA1535, and G46 at all doses used with these strains, both with and … how is the rotation of venus differentWebGerm cell mutagenicity Ames test S. typhimurium Result: negative Mutagenicity (micronucleus test) Hamster - male and female Result: negative Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No … how is the royal family doingWebDichloromethane (DCM) is a colorless liquid with a sweet, pleasant odor. The major use of DCM is as a solvent in the pharmaceutical and chemical industry for reactions, purification and isolation of intermediates or products. how is the royal navy fundedHepatic toxicity. Hepatic effects are commonly observed forms of toxicity following inhalation (Burek et al. 1984; Nitschke et al. 1988) or oral (Serota et al. 1986a) dichloromethane exposure in rodents. Changes observed in animals following dichloromethane exposure include liver foci/areas of alteration, … See more In 2011, the Integrated Risk Information System (IRIS) of the U.S. Environmental Protection Agency (EPA) released an updated Toxicological Review of Dichloromethane (Methylene Chloride) (U.S. EPA 2011). In … See more The toxicological review was developed according to the general risk assessment guidelines (National Research Council 1983, 1994). The literature search strategy was based on the … See more In summary, the IRIS Toxicological Review of Dichloromethane (U.S. EPA 2011) developed noncancer reference dose values for oral … See more Dichloromethane metabolism occurs primarily in the liver but also in lung tissues, particularly in mice. The PBPK model structure for dichloromethane traces back to one … See more how is the royal family so rich