Histone lactylation drives
Webb27 maj 2024 · Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma. Genome Biology. 4. Hideo Hagihara, et al. 2024. Protein lactylation induced by neural excitation. Cell Reports. 5. Webb21 okt. 2024 · Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma. Genome Biol. 2024; 22:85. doi: …
Histone lactylation drives
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Webb17 mars 2024 · Pan et al. report a glycolysis/H4K12 lactylation/PKM2 positive feedback loop in microglia that drives the pathogenesis of Alzheimer’s disease (AD). They … Webb24 mars 2024 · Lysine l-lactylation [K(l-la)] is a newly discovered histone mark that can be stimulated under conditions of high glycolysis, such as the Warburg effect. K(l-la) is …
Webb29 maj 2024 · Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or ... in particular the acetylation and methylation of histone proteins and DNA. We also discuss other eminent metabolic modifications such as, succinylation, hydroxybutyrylation, and lactylation, and update the current advances in ... Webb27 maj 2024 · 乳酸化修饰 (lactylation) 为芝加哥大学赵英明教授团队于2024年在Nature杂志首次报道的一种组蛋白翻译后修饰，发挥着基因转录调控的功能[1]。后续研究进一步 …
Webb27 nov. 2024 · Lactylation is a newly found lactate-derived post-translational modification, which is firstly reported on histone protein lysine residues to regulate gene expression. Here, we provided evidence that higher serum lactate level was possibly associated with better prognosis in ischemic stroke patients. Meanwhile, inhibition of endogenous … Webb16 mars 2024 · It is demonstrated that histone lactylation regulates the anti-inflammatory and pro-angiogenic dual activities of monocyte-macrophages by facilitating reparative …
WebbHistone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma.Genome Biology. 4. Hideo Hagihara,et al. 2024. Protein …
Webb23 okt. 2024 · Histone lactylation links metabolism and gene regulation Cells regulate gene expression in part through the chemical labelling of histone proteins. Discovery of … headache and hot headWebbHistone lactylation is a crucial mechanism through which lactate performs its duties and takes part in crucial biological processes, such as glycolysis-related cellular functions … headache and hypotensionWebbHistone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma.Genome Biology. 4. Hideo Hagihara,et al. 2024. Protein … headache and hypertension emergency medicineWebb27 nov. 2024 · Lactylation is a newly found lactate-derived post-translational modification, which is firstly reported on histone protein lysine residues to regulate gene expression. … headache and indigestionWebb2 jan. 2024 · Intracellular lactate drives a recently described type of posttranslational modification, lysine lactylation (Kla), on core histones. However, the impact of lactylation on biological... headache and increased icpWebbSince its first description in 2024 , histone lactylation has been seen in multiple diseases [16, 17], and has also been identified as a crucial orchestrator for the tumorigenesis by driving oncogenic gene expression . However, the role of histone lactylation remains an important knowledge gap in our understanding of ccRCC pathogenesis. headache and hip painWebb7 juni 2024 · Given that histone lactylation can activate gene transcription and drive tumorigenesis (e.g., with ocular melanoma) 7, we speculated that lowering the SIRT2 … goldfinch bird box