Lactate chemoresistance
WebJan 9, 2024 · Breast cancer is presently the most predominant tumor type and the second leading cause of tumor-related deaths among women. Although advancements in diagnosis and therapeutics have momentously improved, chemoresistance remains an important challenge. Tumors oppose chemotherapeutic agents through a variety of mechanisms, … WebOct 23, 2024 · The high levels of lactate accumulation in tumor microenvironment has been associated with certain key features of tumor progression including senescence …
Lactate chemoresistance
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WebJun 1, 2024 · Lactate promotes chemoresistance through its G-protein coupled receptor GPR81 (lactate receptor/ h ydroxy c arboxylic a cid r eceptor-1; HCAR-1). HCAR-1 …
WebCurcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1. Curcumin has been demonstrated to … WebAccordingly, knock-down of MCT1 or application of the specific MCT1-lactate import inhibitor decreased the chemoresistance of these PDAC cells. In line with the fact that refractoriness to chemotherapy is a hallmark associated with cancer stemness [ 41 , 42 , 43 ], we could further show that MCT1-driven lactate uptake favors stemness properties.
WebHexokinase II and Chemoresistance. The Warburg effect is associated with increased glycolysis as a result of upregulation of several major glycolytic enzymes. The upregulation of hexokinase (HK) activity due to Warburg effect has been implicated in chemoresistance in many cancer types including OVCA [69]. The HK family has four main isoforms ... WebNational Center for Biotechnology Information
WebAlthough the Warburg effect, ie, aerobic glycolysis, involves incomplete oxidation of glucose leading to the production of lactate and resulting in reduced efficiency of glucose metabolism, 23 it is a major feature of tumor cells and plays an important role in tumor development. 24,25 It has been reported that decreasing glycolysis mediated by ...
WebChemoresistance is one of the main causes of poor prognosis in GC. In the 97 GC cases collected in SYSUFAH, we further performed a subgroup analysis of patients who underwent tegafur gimeracil oteracil potassium capsule (S‐1) plus oxaliplatin (SOX regimen) after surgery. ... Lactate is significantly elevated in many tumors, 29 and an elevated ... custom belleville spring washerWebAug 28, 2024 · The lactate receptor, also known as hydroxycarboxylic acid receptor 1 (HCAR1/GPR81), plays a vital role in cancer biology. Recently, HCAR1 was reported to enhance metastasis, cell growth, and... custom belly bands for wedding invitationsWebOct 1, 2024 · Lactate is a pleiotropic signalling molecule capable of regulating several biological processes, including immune–inflammatory responses, angiogenesis, and fibrosis. ... [28], favouring chemoresistance. Chemoresistance is also increased by GPR81-dependent increased expression and activity of the drug-exporting transporter ABCB1, … chaska girls traveling basketball tournamentWebApr 5, 2024 · Collectively, our findings suggest that B7-H3 may be a novel regulator of glucose metabolism and chemoresistance via controlling HK2 expression in CRC cells, a result that could help develop... custom bell covers for instrumentsWebApr 8, 2024 · Introduction. Lung cancer is the leading cause of cancer-related death, accounting for approximately 350 deaths per day [].Non-small cell lung cancer (NSCLC) accounts for 80% of all lung cancer cases and remains the dominant pathological type [].Despite rapid advances in the diagnosis and treatment of lung cancer, the overall 5-year … chaska hawks girls basketballWebJan 2, 2024 · Monocarboxylate transporters (MCTs) mediate metabolic symbiosis, by which lactate in cancer cells under hypoxia is exported through MCT4 and imported by MCT1 in less hypoxic regions, where it is used as an oxidative metabolite. ... and a rapid response to genotoxic damage—all of which contribute to the acquisition of chemoresistance [6,7,8,9]. chaska hawks twitterWebNov 13, 2011 · Tumor lactate can predict for metastases and overall survival of patients, as shown by several studies of different entities. Metastasis of tumors is promoted by … chaska hawks girls tennis