P53 dynamics control cell fate

Author: gzgv

August undefined, 2024

WebA System to Quantify p53 Dynamics and Cell Fate in Single Cells We developed a system to measure p53 dynamics and cell fate in single human colon cancer cells (HCT116) following cisplatin treatment. Cisplatin was previously shown to induce p53-dependent apoptosis in HCT116 cells ( Berndtsson et al., 2007 , Zhu et al., 2013 ). WebJan 8, 2024 · In this work, we employ landscape and flux theory to investigate underlying mechanisms of p53-regulated cell fate decisions. Based on a p53 regulatory network, we quantified the potential landscape and probabilistic flux for the p53 system. ... A. Loewer, and G. Lahav, “ p53 dynamics control cell fate,” Science 336, ...

PDCD5 functions as a regulator of p53 dynamics in the DNA …

WebMar 1, 2024 · PTMs can be specific to the type of DNA damage 120, 121, 122, 123, 124, 125, 126 and thus can accordingly direct the p53-mediated response and cell fate. Fig. 2: Regulation of p53 target... WebJan 7, 2016 · Signaling dynamics are known to encode and decode cellular information that controls cellular responses (Purivs and Lahav, 2013). p53 dynamics can control cell fate decision in response to DSBs, and cells that experience p53 pulses recover from DNA damage, whereas cells that are exposed to sustained p53 signaling frequently undergo … pistola llama max

Stem cell competition driven by the Axin2-p53 axis ... - ScienceDirect

WebApr 20, 2024 · Cell Death & Differentiation - p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways ... Mock C, Batchelor E, Loewer A, Lahav G. p53 dynamics control cell fate. Science ... WebJan 19, 2016 · inhibition modulates p53 dynamics and cell fate in response to DNA damage ABSTRACT A functional DNA damage response is essential for maintaining genome integrity in the presence of DNA double-strand breaks. It is mainly coordinated by the kinases ATM, ATR, and DNA-PKcs, which control the repair of broken DNA strands and relay the damage atmega datenblatt

Cell-to-cell variability in Myc dynamics drives transcriptional ...

Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate …

WebDec 1, 2024 · Furthermore, Purvis et al. [7] and Chen et al. [8] indicated that p53 dynamics control cell fate between life and death in the DNA damage response. These mean that a deep understanding of the dynamics of p53 regulatory network in DNA damage response is extremely meaningful for developing cell control strategies. Webp53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has … atmega buttonWebNov 10, 2024 · p53 dynamics play a key role in cell fate decision. The p53 level exhibits distinct dynamic modes depending on the cell and stress types [ 13]. For example, uniform pulses can be evoked upon ionizing radiation, whereas only a dosage-dependent single pulse appears in response to ultraviolet (UV) radiation. atmega ddrb

"WebFeb 16, 2024 · As a TF, p53 controls the expression of several hundreds of genes [ [ 2]] and is thereby able to induce cell fates ranging from cell cycle arrest to senescence and apoptosis upon DNA damage [ [ 3] ]. Many tumours have mutations either of p53 itself or of members of its signalling pathway underlining its importance as a tumour suppressor [ [ 4] ]. " - P53 dynamics control cell fate

P53 dynamics control cell fate

Global Inhibition with Specific Activation: How p53 ... - Molecular Cell

WebFeb 9, 2024 · p53 dynamics; cell fate decision; cell signaling network 1. Introduction Cells are constantly bombarded by a variety of endogenous and environmental stress that … Web(D) Left: Myc dynamics in cells born before hour 20 of imaging were grouped by cell fate (determined within 4 days after initial drug treatment). Mean ± SEM. Right: mean Myc …

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http://lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2024.04.032 WebDec 1, 2024 · The dynamics of p53 regulatory network in DNA damage response are investigated through analytic analysis and numerical methods. It turns out that the pulsatile behavior can be generated due to initial DNA damage signals and ATM shows a switch-like behavior and relays the DNA damage signal.

WebInduction of p53 triggers multiple cellular programs ranging fromtransientresponses,suchasDNArepairand cell cycle arrest, to terminal fates such as … WebJan 23, 2024 · The dynamics model of tumor suppressor p53 system is employed to investigate how PTEN protein mediates p53 dynamics after DNA damage and it indicates that the moderate p53-dependent PTEN synthesis rate is required for p53 to oscillate, while the higher p53-dependent PTEN synthesis rate is needed for the p53 bi-stable switch. 1 …

WebJul 28, 2009 · Finally, in the cell fate decision module, p53 controls the expression of the target genes; cell cycle arrest and apoptosis are separately evoked by the induction of p21 and p53AIP1. Thus, the damage signal is transmitted forward until DNA repair is completed or apoptosis is initiated. WebOct 1, 2014 · When sustained induction of p53 activity was artificially stimulated by a temporally scheduled dose of the small molecule Nutlin-3, which inhibits Mdm2, cells chose the fate of senescence rather than apoptosis (Fig. 2C), suggesting that p53 oscillation functions as a cell fate determinant (Purvis et al., 2012).

WebJul 18, 2024 · In this review, we discuss the evolution of kinetic p53 modeling, multiple mechanisms for distinct p53 dynamics, and how the temporal p53 dynamics determine cell fate over the last 2 decades.

WebApr 11, 2024 · As the variable p53 levels resulted from the distinct p53 dynamics played a key role in promoting alternative cell fate outcomes of cell cycle arrest and cell death, as we elucidated before [ 15 ], it is important to understand the quantitative and mechanistic basis of the differential dynamic outputs of p53 pathway, which we elaborated below. atmega 328p dipWebMar 1, 2024 · The magnitude of p53-induced gene activation, combined with the stability of the induced mRNAs, determines protein levels in the cell, which ultimately guide cell fate … pistola m20WebJun 15, 2012 · p53 Dynamics Control Cell Fate Authors: Jeremy E Purvis Kyle W Karhohs Caroline Mock Harvard Medical School Eric Batchelor Request full-text Abstract Cells … atmega can busWebFeb 9, 2024 · To determine whether the dynamical patterns in p53 levels were reflected in the expression of its target genes, we quantified the mRNA expression dynamics of three … pistola m200National Center for Biotechnology Information pistola m26WebDec 6, 2013 · If p53 dynamics are controlled directly through chemical manipulation, converting pulsatile dynamics into sustained dynamics is sufficient to switch the cell fate ( 3 ). Evidently, the cell uses p53 dynamics to encode distinct input signals and decodes these dynamics to determine cell fates. atmega delayWebJan 23, 2012 · Induction of p53 triggers multiple cellular programs ranging fromtransientresponses,suchasDNArepairand cell cycle arrest, to terminal fates such as … atmega dfp