The malate-aspartate shuttle
Splet免责声明：本文来自互联网，文章内容仅供参考！ 这种穿梭机制主要在肝、肾、心中发挥作用，其穿梭机制比较复杂，不仅需借助苹果酸、草酸乙酸的氧化还原，而且还要借助α酮 … SpletThe malate-aspartate shuttle (MAS) and its specific metabolic functions in the CNS and liver, respectively. The MAS translocates electrons produced during glycolysis across the inner...
The malate-aspartate shuttle
Did you know?
SpletOver the last few years, various inborn disorders have been reported in the malate aspartate shuttle (MAS). The MAS consists of four metabolic enzymes and two transporters, one of … Splet11. sep. 2024 · Recent studies showed that mitochondrial components of the malate-aspartate NADH shuttle act as a longevity factor that induces the extension of lifespan in …
SpletThe malate-aspartate shuttle is the principal mechanism for the movement of reducing equivalents in the form of NADH from the cytoplasm to the mitochondrion. Cytoplasmic … Splet14. feb. 2006 · The malate-aspartate shuttle is considered the most important shuttle in brain. It is particularly important in neurons and may be extremely low, or even non …
SpletPred 1 dnevom · One such cycle is the malate-aspartate shuttle (MAS), which uses malate as intermediate electron carrier to transport the electrons from cytosolic NADH to … SpletThis pathway is known as the malate-aspartate shuttle, because it involves exchange of mitochondrial aspartate for cytosolic malate: aspartate from the mitochondria crosses to the cytosol. aspartate is transaminated (at the expense of ketoglutarate) to yield oxaloacetate oxaloacetate is reduced to malate by cytosolic NADH
SpletAbstract Citrin, encoded by SLC25A13, is a component of the malate-aspartate shuttle, which is the main NADH-transporting system in the liver. Citrin deficiency causes neonatal intrahepatic cholestasis (NICCD), which usually resolves within the first year of life.
Splet21. sep. 2008 · The M–A shuttle comprises a transport–transamination–redox cycle in both cytosolic and mitochondrial domains. There are two antiporter proteins located in the … jeremy lamb injurySplet25. jan. 2024 · To transfer cytosolic NADH into mitochondria, cancer cells need the malate-aspartate shuttle (MAS), which is composed of two antiporters, the malate-α-ketoglutarate antiporter SLC25A11 (also known as oxoglutarate carrier, OGC) and the glutamate-aspartate antiporter SLC25A12 (also known as aspartate-glutamate carrier isoform 1, … jeremy langloisSpletPred 1 dnevom · One such cycle is the malate-aspartate shuttle (MAS), which uses malate as intermediate electron carrier to transport the electrons from cytosolic NADH to mitochondrial NADH [8]. The other cycle is the glycerol-phosphate shuttle (GPS), which uses Glycerol-3-phosphate as intermediate to transport the electrons over the membrane to … la martina damen saleSpletCitrin is aspartate/glutamate transporter in mitochondria, a component of malate-aspartate nicotinamide adenine dinucleotide hydrogen shuttle, and is essential for the hepatic glycolysis. Although the precise pathophysiology of citrin deficiency remains unclear, recent reports for the effective MCT supplement therapy and downregulation of ... jeremy lane seahawksSpletthe malate–aspartate shuttle has been debatable until the transporters required for the malate–aspartate shuttle to operate were identified (Palmieri et al. 1996, 1999, 2001; … la martina bermuda shortsSplet11. sep. 2024 · The malate–aspartate shuttle for transporting reducing equivalents from cytosolic NADH into the mitochondrial matrix (after figure 18–25 of Lehninger's … jeremy lamb nba rumorsSplet20. apr. 2024 · Malate-aspartate shuttle (Malate shuttle): This shuttle system is more common and universal. This shuttle for transporting reducing equivalents from cytosolic NADH into the mitochondrial matrix … jeremy lane injury